Glp2r expression is most abundant in the lamina propria of duodenal and jejunal villi (Wismann et al., 2017), where in the jejunum its expression within the lamina propria stromal cells predominate in the upper half of villi (Yusta et al., 2019) (Figure 1)

Important Safety Warnings Seek immediate medical attention if you experience: Severe, persistent abdominal pain (possible pancreatitis) Signs of dehydration from vomiting or diarrhea (dizziness, decreased urination, extreme thirst) Symptoms of gallbladder disease (right upper quadrant pain, fever, yellowing of skin or eyes) Severe hypoglycemia (confusion, loss of consciousness, seizures) Allergic reactions (difficulty breathing, swelling of face or throat, severe rash) Vision changes (if diabetic) Rapid or irregular heartbeat with chest discomfort Do not use semaglutide if you have: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to semaglutide or any formulation components Pregnancy or plans to become pregnant (discontinue at least 2 months before conception) Use with caution if you have: History of pancreatitis, severe gastrointestinal disease, diabetic retinopathy, kidney disease, or are taking insulin or sulfonylureas

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This trifecta approach represents a leap forward in understanding how multiple hormonal signals can be harmonized to treat complex metabolic dysfunction