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reported that GLP-1 (7-36) was not found to alter myocardial glucose utilization

The glucagon component, which makes retatrutide fundamentally different from semaglutide and tirzepatide , is what makes retatrutide unique among GLP-1 class medications, and it is also what makes the side effect profile slightly different

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For perspective, if you weigh 200 pounds, that's a difference between losing about 30 pounds on tirzepatide versus 16-17 pounds on semaglutide after a year of treatment