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Microglia are involved in various aspects of DCI, including neuro-inflammation, vasospasm, microthrombosis, and cortical spreading depolarizations ( Microglia contribute to sustained neuro-inflammation and vasospasm through the release of proinflammatory cytokines like TNF, which promotes vasoconstriction (89)

Incorporating sex as a biological variable in future studies will therefore be essential to determine whether males and females may benefit differently from antioxidant-based treatments and to address the current imbalance in ASD research

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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program