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Figure 2: changes in HbA1c levels over the 26 week experimental treatment period

These two compounds target fundamentally different biological systems: testosterone affects androgen receptors throughout the body, while semaglutide primarily engages GLP-1 pathways in the hypothalamus and gastrointestinal tract

Years of post-marketing surveillance for Ozempic (diabetes) and Wegovy (obesity) have generated a robust safety profile that tirzepatide, as a newer molecule, is still building