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These outcomes lead to the remodeling of the extracellular matrix, oxidative stress, inflammation, cardiomyocyte apoptosis, fibrosis, and metabolic abnormalities [55]
Annus T, Wilson LR, Acosta-Cabronero J, Cardenas-Blanco A, Hong YT, Fryer TD, Coles JP et al (2017) The Down syndrome brain in the presence and absence of fibrillar -amyloidosis
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