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Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
The studies have suggested that in comparison with rodents, relatively little AFB1-GSH conjugate is produced by human liver, but insufficient data exist to be certain that this reaction is not of physiological importance in man, particularly as an aflatoxin mercapturate has been detected in the urine of marmoset monkeys treated with AFB 1
Gigliotti contrasts such a patient with a person who has a BMI of 40 and diagnoses of hypertension, type 2 diabetes, CVD, and musculoskeletal issues, who may benefit from lifelong use of weight management medications
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