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Proceedings of the National Academy of Sciences USA , 115(10), E2320-E2328

Synthesis of ROS-sensitive polymers conjugated with Ru(II)-OH (P4) At room temperature, 4-Dimethylaminopyridine (DMAP, 126 mg) was introduced to a solution of Ru(II)-OH (50 mg) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCl, 200 mg)

In simple terms, microdosing refers to using a fraction of a standard therapeutic dose , often around 1025% or less, taken regularly to see whether milder effects still provide benefit

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