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Since an intramolecular disulfide bond forms between the N- and C-terminal CRDs (Cys310-Cys629 and Cys303-Cys598), the higher amounts of reactive oxygen species cause Yap1 to undergo transitory redox-induced conformational changes that hide the NES

Chronic inflammation prompts specialized liver cells to produce scar tissue, leading to fibrosis of the liver

doi: 10.1038/nrd.2017.162 33 KhomichO

Its role is also being investigated for Alzheimers disease and dementia, cardiovascular and peripheral artery disease, insulin resistance and diabetes, infertility, osteoarthritis, athletic performance enhancement, and weight loss