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The researchers say the finding suggests several potential clinical applications, including treating patients with metabolic conditions such as diabetes and obesity who are also experiencing depression and targeting depression through probiotic intervention
Non-12-OH FXR-antagonistic BAs mediates the T3 effect on glucose homeostasis To dissect the contribution of the augmentation of non-12-OH FXR-antagonistic BAs to the improved glucose metabolism after T3 daily injection, MMI mice were fed a diet supplemented with TMCA, the most abundant murine FXR-antagonistic BA, for five days
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