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Due to the promotive effect of GLP-1R agonism on -cells proliferation and survival, concerns of tumorigenesis, especially pancreatic cancers, have been raised about incretin-based therapies (89)
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It has documented effects on gut microbiome composition and may support gut health through prebiotic fermentation
Patients that choose to use these medications at high doses to lose weight rapidly will more than likely pay the price dearly with other health issues and weight gain if they discontinue the peptide
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