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GLP-1 receptor agonists, including semaglutide (sold as Ozempic and Wegovy), were originally developed to treat type 2 diabetes
Oncotarget 6:2200622027 Esworthy RS, Mann JR, Sam M, Chu FF (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage
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Glutathione serves as a coenzyme contributing a thiolate as a base in the isomerase mechanism, which also involves the active-site Tyr9 and Arg15
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