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Estrogen signals through peroxisome proliferator-activated receptor- coactivator 1 to reduce oxidative damage associated with diet-induced fatty liver disease

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However, lixisenatide inhibited the A-induced activation of GSK-3, with a significant increase in the phosphorylation of ser9 and a significant decrease in the phosphorylation of Y216, suggesting that lixisenatide can prevent A-related impairments by affecting the PI3K-Akt-GSK3 pathway (179)

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