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Wegovy and Zepbound are restricted by tighter BMI criteria, longer weight management program requirements, and step therapy
The average reported loss is about 1.5% of body weight per week at therapeutic dose, though individual results depend on starting weight, adherence, and lifestyle factors
GLP-1RAs modulate immune cell signaling and regulate the nuclear factor-kappa B (NF-B) pathway, impacting inflammatory responses, cytokine production, and oxidative stress attenuation
Specifically, the ELIXA (lixisenatide) trial studied patients with T2DM who had recent acute coronary syndrome and found that the addition of lixisenatide to conventional therapy did not result in a significant difference in cardiovascular endpoints relative to placebo (Table 1) [56]
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