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One notable barrier is that GLP-1 receptor agonists have historically been administered via SC injection only
134 WatanabeH.SaitoR.NakanoT.TakahashiH.TakahashiY.SumiyoshiK.et al (2014)
Irregular dosing patterns may lead to less predictable blood glucose control, potentially increasing the risk of hypoglycemia (especially when combined with insulin or sulfonylureas) or periods of inadequate glucose management
Because these are newer formulas and newer compounds, it definitely requires more accumulation of evidence from different populations with longer follow-up to reach definitive conclusions. The investigators plan to use Indianas statewide electronic health record database to further investigate the impact of GLP-1 agents on cancer risk
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