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Collagen hydrolysates (composed of dipeptides and tripeptides), thought to be resistant to peptidase activity during digestion [27, 29], can enter the blood and be subsequently transported to the skin to yield positive effects on hydration and elasticity and improve wrinkles, particularly in aging women [26,27,28,29, 31]
In many of the clinical trials comparing GLP-1RAs with sitagliptin, more than 50% of the participants treated with GLP-1RA achieved this weight loss benchmark (102)
Moss M, Oliver L
This provides a theoretical basis for uncertainty management, serving as a crucial caveat for clinicians: when utilizing GLP-1RAs, one must distinguish between the relative certainty of metabolic benefits and the stochastic nature of reproductive improvements
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