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Moreover, existing studies mostly focus on the regulation of RA synovial cells (such as FLS) or macrophages by the cGAS-STING pathway, whereas this study, for the first time, clearly demonstrates the central role of the cGAS-STING-ferroptosis axis in RA chondrocytes, and reveals that GLP-1RAs exerted therapeutic effects on RA through a dual mechanism of directly inhibiting this axis and simultaneously promoting the M2 polarization of macrophages

Tip 2 Diyabet Hastalar GLP-1 analoglar balangta kan ekeri dzenlemesi iin gelitirilmitir

The medication slows gastric emptying

Several studies have identified ACSL4 and LPCAT3 as key determinants of susceptibility to ferroptosis, especially ACS4, which is considered a biomarker of ferroptosis (42)