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All of the disproportionality signals had early failure type features, suggesting that the majority of patients developed gastrointestinal AEs within 1 week or 1 month of semaglutide treatment, and that the risk of gastrointestinal AEs occurrence gradually decreased over time

The MHRA has not approved any GLP-1 receptor agonist for use below the labelled doses, and this approach falls outside current prescribing guidelines

There are signs of infection in or near the bruise (increasing redness, warmth, pus, fever)

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