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Any observed biological effects are specific to experimental models and conditions and are not equivalent to established clinical outcomes
Expression and cellular immunogenicity of a transgenic antigen driven by endogenous poxviral early promoters at their authentic loci in MVA
Most of the studies that reported syncytia-formation in virus-free systems that employed widely used model cell lines like HEK293T (human kidney cells), HeLa (human cancer cells), Calu-3 (human lung cells) or Huh-7 (human liver cells), which are overexpressing ACE2, and the used plasmid-based transfection systems further contribute to generate artificial conditions that limit a direct translation of the obtained results to realistic in vivo situations
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