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Studies showing that addition of cysteine, glutamate, or glycine does not enhance glutathione synthesis also support the role of GCL as a metabolic control point in the pathway (Meyer and Fricker, 2002)

12964_2025_2068_MOESM2_ESM.tif (download TIF Supplementary Material 2: Supplementary Figure 2

Reactive oxygen species result in the formation of free radicals, highly reactive molecules which cause cellular and tissue damage in the form of oxidative stress

At hormonal levels, Copper Tripeptide-1 acts as a chemoattractant for fibroblasts (repairing cells) and activates a plethora of regenerative processes in the skin, such as angiogenesis, production of extracellular matrix components, including collagen, elastin, proteoglycans, glycosaminoglycans, etc, additionally activating metalloproteinases (MMPs) involved in tissue remodeling