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Pharmacokinetic and pharmacodynamic effects of multiple-dose administration of omarigliptin, a once-weekly dipeptidyl peptidase-4 inhibitor, in obese participants with and without type 2 diabetes mellitus

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However, this single-pathway activation proves insufficient for patients whose weight regulation depends more heavily on GIPR signaling, MC4R pathways, or FTO genetic variants that increase appetite set-point

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