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What to monitor: The same factors as the 1 mg phase, plus blood glucose patterns if you monitor them, hydration status (GLP-1 agonists can reduce thirst cues), and mood or energy shifts that may indicate metabolic transition
46 As such, direct G6PD inhibition by caffeine may constrain the pools of the very NADPH necessary for its direct catabolism or that of its metabolites, such as paraxanthine
People with a history of pancreatitis or severe gastrointestinal disorders may not be good candidates and generally should avoid GLP-1 therapy unless cleared by a specialist, given the potential risks
10.1021/bi001088w
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