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Graphical abstract Access this article Similar content being viewed by others Abbreviations ASBT: Apical Sodium dependent Bile acid Transporter pathway ATP: Adenosine triphosphate API: Active Pharmaceutical Ingredient BMI: Body Mass Index cAMP: Cyclic Adenosine Monophosphate DMN: Dissolving Microneedle DPP IV: Dipeptidyl peptidase IV EGFR: Epidermal Growth Factor Receptor pathways GIT: Gastrointestinal Tract GIP: Gastric inhibitory polypeptide GLP-1: Glucagon Like Peptide-1 HbA1c: Glycated Haemoglobin LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results NEP: Neutral Endopeptidase NLC: Nanostructured Lipid Carrier PEG: Polyethylene Glycol PLA: Polylactic acid PLGA: Poly(lactic-co-glycolic acid) PVP: Polyvinyl Pyrrolidone SGLT2: Sodium Glucose cotransporter 2 US-FDA: United States Food and Drug Administration References Lu X, et al