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While it has gained popularity due to its ability to stimulate fat metabolism without increasing IGF-1 levels, its essential to understand how it differs from other peptides like hGH, CJC-1295, Ipamorelin, and Semaglutide (Ozempic)

MOTS-c interacts with Nrf2, enabling Nrf2 to recognize and bind to antioxidant response elements (ARE), which initiates the transcription of target genes and directly regulates ARE-containing target genes in the nuclear genome 61,62

In the STEP 13 clinical trials conducted between 2018 and 2020, semaglutide was shown to significantly reduce inflammatory markers