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Characteristics of DOR-containing regimen and prior ART regimen The single agent formulation of DOR, used in combination with other ARVs to form a complete regimen, was prescribed to 73% of the study population, while the remaining 27% of the population received the fixed dose combination of DOR/TDF/3TC

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Frontiers in Nutrition, 11, 1493593

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This gives you a clear reference point for the 28-day post-puncture limit

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The evidence is mixed, with some studies suggesting DSIP does not induce tolerance while user reports sometimes indicate diminishing returns with daily use

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