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Compared with diabetic controls without ligation (DB-Con), DB-Lig mice showed worse glycemic control and more severe pancreatic dysfunction, as demonstrated by random blood glucose, glycated serum protein, intraperitoneal glucose tolerance test (IPGTT), insulin tolerance test (ITT), and pancreatic insulin/glucagon immunofluorescence staining (Fig S7be)

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As a result, there was a significant reduction in primary endpoints across all studies (CV death, nonfatal MI and nonfatal stroke)