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In chronic metabolic states like obesity and T2DM, the GLP-1R signaling axis undergoes significant alterations that drive incretin resistance and impaired glucose control (Rabbani and Thornalley, 2024
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The arrival of a powerful weight-loss pill signals that these medications are moving from niche, expensive, injection-based therapies into something closer to everyday medicine
"Providers who had diversified beyond compounded weight loss into adjacent wellness categories like hair loss and ED, or had already begun offering branded options, were simply better positioned to absorb the shock," Aslam said in an interview
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