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Amino acid sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 Molecular weight: ~1024.18 Da Molecular formula: C50H69N15O9 Number of amino acids: 7 (with N-terminal acetylation and C-terminal amidation) Cyclization: Lactam bridge between Asp (side chain carboxyl) and Lys (side chain amino) Ring size: 23-membered macrocyclic lactam Key modifications from alpha-MSH: Nle4 replaces Met4 (oxidation resistance), D-Phe7 replaces L-Phe7 (increased potency), truncation to 7 residues, cyclization via Asp-Lys lactam Contains D-Phe (non-natural stereochemistry at position 7) N-terminal: acetylated
they help increase serotonin levels and thereby alleviate OCD symptoms
MK-677 (Ibutamoren) Bottom line: MK-677 is more convenient but creates continuous (not pulsatile) GH elevation and has more metabolic side effects
Three authors of the systematic review were on the guideline panel (Li L, Suetonia P, Farid F)
