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It participates in over 200 enzymatic reactions spanning: DNA methylation attaching methyl groups to cytosine bases at CpG sites, controlling which genes are expressed or silenced Histone methylation modifying chromatin architecture, determining gene accessibility Neurotransmitter synthesis methylating norepinephrine epinephrine, and supporting serotonin/dopamine metabolism Phosphatidylcholine synthesis building cell membrane phospholipids via the PEMT pathway Creatine synthesis approximately 40% of total SAM-e consumption goes to creatine production Detoxification liver phase II methylation of hormones, heavy metals, and xenobiotics After donating its methyl group, SAM-e becomes SAH (S-adenosylhomocysteine), which is then converted to homocysteine
Glucosinolates may offer protection against certain cancers by modulating the activity of enzymes that detoxify carcinogens and metabolize sex hormones
More severe reactions involving widespread hives, swelling, difficulty breathing, or dizziness require emergency medical care
The Bottom Line Vitamin B12 injections can help if your gut doesnt absorb nutrients well or you dont want to take a daily oral supplement
