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Most of the affected metabolites showed elevated metabolite levels, while alanine, heptanoic acid, glutamate, glutamine, pyroglutamate and hydroxyproline were reduced

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The third phase 3 clinical trial is the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) Next Generation trial (DIAN-TU-001 (E2814), NCT05269394), in which a combination of lecanemab and the anti-tau antibody E2814 (phase 2) will be administered to 168 people with familial AD mutations