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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon
Type 2 diabetes mellitus is a common obesity-related complication in PWS and is diagnosed in 7-24% of adults with PWS compared to 5-7% in the general population (45, 46)
5a, Supplementary Fig
Grilled chicken, fish, turkey, eggs, Greek yogurt Plant options: Tofu, tempeh, beans, lentils Non-Starchy Vegetables High-fiber vegetables may help with constipation - a common GLP-1 side effect many people experience
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