People who think they are getting enough protein are frequently hitting only 40 to 60 grams daily, which is well below the threshold for muscle preservation during active weight loss
According to Monelle Burrus, nurse practitioner and founder of Verve Health weight loss clinic in Oregon, There will always be skin damage if the needle pierces small blood vessels in the area that will be injected. On top of that, Certain areas of the body, like the abdomen or thigh (common injection sites), may be more prone to bruising due to blood vessel density or tissue sensitivity, says Dr
This stepwise escalation principle mirrors the approach used for licensed medicines such as semaglutide (Wegovy, UK SmPC available via the electronic Medicines Compendium) and tirzepatide (Mounjaro, UK SmPC available via the electronic Medicines Compendium), both of which are approved by the MHRA and recommended within relevant NICE guidance for specific indications
The Phase 3 TRIUMPH-4 trial focused on 8mg and 12mg doses