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Mitochondria are the microscopic powerhouses of our cells, responsible for generating adenosine triphosphate (ATP), the fundamental energy currency required for every biological process, from muscle contraction to cognitive processing
Therefore, semaglutide, tirzepatide, and retatrutide are expected to be safer and more effective treatments for MC4R-deficient obesity than setmelanotide
Semaglutide primarily mimics the GLP-1 hormone, focusing on appetite suppression
Long-chain fatty acids cannot cross the inner mitochondrial membrane on their own and it is inside the mitochondrion that they are burned (-oxidation)
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