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Activated HIF-1 enters the cell nucleus, where it binds to the promoters of the xanthine dehydrogenase (XDH) and 5-nucleotidase II (NT5C2) genes, thereby upregulating the expression of XDH and NT5C2

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Better for chronic inflammatory conditions like arthritis

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Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation

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