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Daniel Drucker, MD, an endocrinologist at the University of Toronto in Canada, said the impressive data from these phase 3 clinical trials has led to widespread acceptance of the cardiovascular benefits of GLP-1s, particularly semaglutide

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10.1016/j.jchf.2014.04.005 193 WrightD

this effect may counteract the cardiovascular complications by the reduction of the systemic inflammation ( Figure 1 3.2 GLP1-RAs and AMPK GLP-1 (Glucagon-like peptide 1) is an incretin hormone, secreted from L-cells of the small intestine in a glucose-dependent manner, that enables stimulation of insulin secretion, increases pancreatic -cell mass, and inhibits glucagon secretion and gastric emptying, thereby reducing postprandial glycemia