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In the primary trial assessing 14,068 individuals receiving semaglutide versus 13,154 propensity score-matched individuals receiving empagliflozin, the incidence of the primary outcome was 1.9% versus 2.2% at 1 year, 3.7% versus 4.5% at 2 years, and 5.9% versus 6.9% at 3 years for the semaglutide-treated and empagliflozin-treated groups, respectively

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

Mol Metab 2021;51:101237.ArticlePubMedPMC 10

Published research has documented combined cAMP and IP3 signalling, CREB phosphorylation, and downstream GH gene (GH1) expression