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3 Results 3.1 SE ameliorates metabolic dysfunction, cognitive deficits, and hippocampal neurodegeneration in diabetic mice To establish a DCI model, we fed mice an HFD combined with STZ injections (Figure 1A)

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For this analysis and all other analyses comparing protein abundance at week 68 to baseline, we excluded individuals in both the placebo and treatment arms that were not on treatment at week 68

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