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Ozempic and other GLP-1 receptor agonists dampen mesolimbic dopamine signaling, reducing reward salience and drug reinforcement across addictions

doi:10.1016/j.regpep.2004.04.013 2022 The Author(s)

Requena B, et al

It's typically worst in the first one to two weeks after starting treatment or moving up to a new dose, as your body adjusts to the medication's effects on blood sugar, appetite and digestion