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Individuals with severe kidney or liver disease, unless closely monitored and approved by a healthcare provider

According to USDA Agricultural Research Service data based on NHANES, approximately 6% of adults aged 60 and older in the United States are vitamin B12 deficient, defined as plasma B12 below 148 pmol/L (2009)

If you have uncontrolled hypertension, heart failure, or a history of heart attack, you should avoid regular ibuprofen use

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