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In the MVP cohort 20 , rs10305420 is associated significantly with BMI-associated traits ( P value around 2 10 15 ), although it is in linkage with an upstream association (Extended Data Fig

A total of three cytosolic isoforms of MDHARs have been reported in the moss Physcomitrella patens (Lunde et al., Physcomitrella apparently lacks any chloroplastic isoform indicating that AsA reduction in the plant exclusively occurs in cytosol (Drew et al., In order to protect against the deleterious effects of ROS, the AsA pools are required to be maintained in a reduced state