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Both Retatrutide and Cagrilintide are built for once-weekly subcutaneous dosing thanks to their long half-lives
GLP-1 agonists mimic the GLP-1 hormone, helping regulate insulin, glucose, and appetite
The short half-life of native GLP-1, typically only 12 min due to rapid degradation, has facilitated the development of structurally modified GLP-1 analogs with longer half-lives, such as liraglutide, exendin-4, and dulaglutide, which exhibit 97%, 53%, and 90% sequence homology, respectively 12
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