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Tirzepatide, a newer GLP-1/GIP dual agonist, and retatrutide, a triple agonist still in trials, have pushed results even further, with average weight loss approaching 2025% of body weight

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1 At high concentrations K m ) m max Clinical Implications of Michaelis-Menten Kinetics Drugs that have a therapeutic range that falls on the steep, transitional part of the Michaelis-Menten curve are said to have a narrow therapeutic index and pose significant clinical challenges