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389 GLP-1RAs and fat metabolism GLP-1RAs work via numerous mechanisms that contribute to weight loss, one of the most well-known of which is the gut-brain axis

Key variables in study design include: Route of Administration: Will the compound be studied via systemic injection (subcutaneous, intramuscular) or a more localized injection near the site of injury

This so-called buffering capacity in the muscles provided by carnitine can help reduce lactate accumulation, which can result if acetyl-CoA concentrations continues to rise during high intensity exercise

Here, we demonstrated that the GST tag is a substrate for TG2 and that crosslinking between the GST tag and other TG2 protein substrates is responsible for the formation of GST fusion protein aggregates during pulldown experiments