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PET-NP exposure resulted in a higher mortality incidence in both MI + NP-exposed mice, who received 50 g/ml oral PET-NPs, and in mice exposed to PET-NPs by aerosol inhalation (12-h continuous exposure to PET-NPs at 1 mg/m3 by aerosol inhalation every day for 3 months)
Consistent with this, glutaminolysis-derived -KG promotes M2 activation by increasing fatty acid oxidation and Jmjd3-dependent epigenetic reprogramming of M2-related genes 142
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This cascade amplifies antioxidant defenses and enhances resilience against oxidative insults in reproductive tissues
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