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Since a proportion of arterial blood first enters islets cells, it is likely that RXS generated in CYP-induced islets are delivered to some acini by the insulo-portal conduit, so adding to their RXS burden, and potentially explaining the patchy distribution of lesions (24, 147, 165)

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High Glucose Decreases Intracellular Glutathione Concentrations and Upregulates Inducible Nitric Oxide Synthase Gene Expression in Intestinal Epithelial Cells