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However, the report describes the woman's symptoms as "idiosyncratic" and concedes they may have been caused by another ingredient in her supplement.33 Even if you feel that your risk of adverse events is low, we recommend speaking with your doctor before incorporating milk thistle (or any supplement) into your regimen

Department of Rehabilitation Medicine, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215008, China

Matsubara N, Mukai H, Itoh K, Nagai S

You might also hear it called a Herxheimer reaction or JarischHerxheimer reaction the same principle applies: when many pathogens die at once, they release toxins that trigger temporary inflammatory symptoms (source, source)