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10.1101/gad.926401 Genes Dev
Additional studies are needed to determine safety and efficacy of NAC for various conditions
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Key uncertainties include the human translational relevance of the gliopeptide system, the stability and bioavailability of TDN in humans, potential off-target CNS effects, and the consequences of chronically manipulating glial function. To continue investigating TDN and other ODN derivatives, the press release stated that a new biotech company called CoronationBio has licensed the intellectual property from Syracuse University and the University of Pennsylvania and plans to begin human trials in 2026 or 2027.
