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KPV exerts its primary anti-inflammatory activity through direct intracellular penetration of immune cells and intestinal epithelial cells, where it suppresses NF-B transcription factor activity the master regulator of pro-inflammatory cytokine gene expression through a receptor-independent intracellular mechanism, resulting in downstream reduction of IL-6, IL-8, TNF-, and related inflammatory mediators
Mitochondria are the main source of ROS, generated from the ETC/OXPHOS and any excess release of toxic free radicals could trigger OxS and m -Dys 589
Kurata M et al
Depth reduction: As new collagen fills the dermal void, the visible depth of stretch marks decreases
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