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Disrupting MYSM1 (Myb like, SWIRM and MPN domains 1), a histone deubiquitinase, can compromise human HSC function, mimicking the bone marrow failure seen in patients, by triggering lipid peroxidation and ferroptosis [203]

The most common locations in the CNS are lobar (53.1%), posterior fossa (17.3%), and pineal region (13.6%) (6)

The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords