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Although not as statistically meaningful, other supplements were associated with the following increases in the risk of death during the study: multivitamins (2.4%), vitamin B6 (4.1%), folic acid (5.9%), magnesium (3.6%), zinc (3.0%), and copper (18.0%)
They carry a lower addiction risk than stronger opioids but still require careful prescribing
Some facilities use both approaches together for difficult wounds, though research on combined protocols is limited
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