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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)
Avoiding unwanted targets: If peptide binds receptors primarily on cells not involved in disease, less likely providing benefit
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Urticaria, pruritus without rash, and angioedema have been reported in less than one percent of patients
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